Endocrine Abstracts

Signal transducer and activator of transcription 6(STAT6) is involved in epithelial cell growth. However, little is known regarding the STAT6 phosphorylation status in Graves’ disease (GD) and its role in thyroid epithelial cells (TECs). In this study, we found that STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both GD patients and experimental autoimmune Graves’ disease mice and that STAT6 deficiency ameliorated GD symptoms. Autocrine IL-4...

Problem: Interleukin-17A (IL-17A) has a role in sustaining normal pregnancy. IL-17A is also associated with thyroid autoimmunity during pregnancy. This study sought to investigate whether IL-17A is a risk factor for thyroid dysfunction during pregnancyin women negative for thyroid autoantibodies.Methods of study: The study comprised 216 pregnant women with negative thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) during the second tr...

Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function along with thyroid autoimmunity in pregnant women during the second trimester. 1592 pregnant women were recruited from the obstetric outpatient department during the second trimester. Serum ferritin (SF) level...

B lymphocytes are the source of autoantibodies against the thyroid--stimulating hormone receptor (TSHR) in Graves’ disease (GD). Characterization of autoimmune B-cell expression profiles might enable a better understanding of GD pathogenesis. To reveal this, the expression levels of long noncoding RNAs (lncRNAs) and mRNAs (genes) in purified B cells from patients with newly diagnosed GD and healthy individuals were compared using microarrays, which elucidated 604 differe...

Problem: Interleukin-17A (IL-17A) has a role in sustaining normal pregnancy. IL-17A isalso associated with thyroid autoimmunity during pregnancy. This study sought to investigate whether IL-17A is a risk factor for thyroid dysfunction during pregnancy without thyroid autoimmunity.Methods of study: The study comprised 216 pregnant women with negative thyroid peroxidase antibody (TPOAb) andthyroglobulin antibodies (TGAb) during the second trimesterwho prov...

Background: Graves’ disease (GD) is a common autoimmune disorder characterized by the production of autoantibodies targeting the thyroid, leading to hypothyroidism. It is widely accepted that B lymphocytes play a significant role in GD as they are the source of autoantibodies (TRAb) against the thyroid-stimulating hormone receptor (TSHR). Previously, we reported that B cells infiltrate the thyroid tissue of GD patients, and in this study we observed that the percentage of...

There are potential benefits and risks to receive Granulocyte-Colony Stimulating Factor (G-CSF) as a general treatment in hospital. To assess the clinical effect of G-CSF or non-G-CSF on recovery duration for agranulocytosis patients with hyperthyroidism, we analyzed the overall clinical outcomes by meta-analysis. We included published seven retrospective studies and 1 prospective study. Individual data were obtained from eight trials (376 patients: 215 with G-CSF, 161 with no...